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American Society of Microbiology ABMM Sample Questions:

1. A patient develops a severe diarrheal illness after returning from a backpacking trip where they drank untreated stream water. Stool examination reveals motile trophozoites with multiple flagella and a prominent ventral sucking disk. The MOST likely causative agent is:

A) Entamoeba histolytica
B) Cyclospora cayetanensis
C) Cryptosporidium parvum
D) Giardia lamblia

2. During an investigation of a foodborne outbreak linked to a church supper, 80 people ate the suspected chicken dish, and 32 subsequently developed gastroenteritis. Among 50 people who did not eat the chicken dish, 5 developed similar symptoms. What is the attack rate among those who ate the chicken dish?

A) 5%
B) 10%
C) 40%
D) 64%

3. A clinical trial is evaluating the efficacy of a new antifungal agent against invasive aspergillosis. Serum galactomannan levels are being used as a biomarker to monitor the infection. A decrease in galactomannan levels during treatment would indicate:

A) Concurrent infection with a non-Aspergillus mold.
B) Development of resistance to the antifungal agent.
C) Successful clearance or reduction of the Aspergillus burden.
D) A false-positive result in the galactomannan assay.

4. What is considered the "gold standard" for routine monitoring of the lethality of steam sterilization (autoclave) cycles in healthcare facilities?

A) Performing a Bowie-Dick test at the beginning of each day for pre-vacuum sterilizers.
B) Regular use of biological indicators containing spores of Geobacillus stearothermophilus.
C) Daily check of autoclave cycle printouts for correct time, temperature, and pressure.
D) Use of chemical indicator strips placed inside each sterilized pack.

5. A patient develops a severe diarrheal illness after consuming raw oysters. Stool cultures grow a Gram- negative, comma-shaped bacterium that is oxidase-positive and grows on thiosulfate-citrate-bile salts-sucrose (TCBS) agar, producing green colonies. The MOST likely virulence factor contributing to the watery diarrhea is:

A) Cholera toxin-like enterotoxin
B) Cytotoxin-associated gene A (CagA)
C) Heat-labile toxin (LT)
D) Shiga toxin

Solutions: